GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| UCEC | cis | rs1577917 | 1 | rs11759855 | chr6:86610841 | SNHG5 | chr6:86386726-86388451:- | -0.45 | -5.39 | 2.62E-7 | Response to antipsychotic treatment |
| UCEC | cis | rs11782652 | 1 | rs11782652 | chr8:82653644 | CHMP4C | chr8:82644688-82671746:+ | -0.81 | -4.78 | 4.12E-6 | Epithelial ovarian cancer;Ovarian cancer |
| UCEC | cis | rs1577917 | 1 | rs117907570 | chr6:86601283 | SNHG5 | chr6:86386726-86388451:- | -0.45 | -5.74 | 4.91E-8 | Response to antipsychotic treatment |
| UCEC | cis | rs12220777 | 1 | rs118110670 | chr10:81792242 | LOC219347 | chr10:81805991-81838949:- | 0.7 | 5.05 | 1.27E-6 | Chronic obstructive pulmonary disease-related biomarkers |
| UCEC | cis | rs9309473 | 1 | rs11893881 | chr2:73824373 | ALMS1P | chr2:73872046-73912692:+ | 0.53 | 6.03 | 1.21E-8 | Metabolite levels |
| UCEC | cis | rs2241437 | 1 | rs11899576 | chr2:86256193 | LOC90784 | chr2:86247339-86250991:- | -0.69 | -6.53 | 9.1E-10 | Response to methylphenidate treatment in attention-deficit/hyperactivity disorder (blood pressure) |
| UCEC | cis | rs9309473 | 1 | rs11899740 | chr2:73631212 | ALMS1P | chr2:73872046-73912692:+ | 0.43 | 4.84 | 3.1E-6 | Metabolite levels |
| UCEC | cis | rs9309473 | 1 | rs11899902 | chr2:73631564 | ALMS1P | chr2:73872046-73912692:+ | 0.52 | 6.13 | 7.2E-9 | Metabolite levels |
| UCEC | cis | rs9309473 | 1 | rs11901272 | chr2:73720444 | ALMS1P | chr2:73872046-73912692:+ | 0.53 | 6.33 | 2.69E-9 | Metabolite levels |
| UCEC | cis | rs9309473 | 1 | rs11903916 | chr2:73815328 | ALMS1P | chr2:73872046-73912692:+ | 0.54 | 6.33 | 2.61E-9 | Metabolite levels |
| UCEC | cis | rs9815354 | 1 | rs11923562 | chr3:41760331 | ULK4 | chr3:41288091-42003660:- | 0.48 | 5.7 | 5.9E-8 | Diastolic blood pressure |
| UCEC | cis | rs9815354 | 1 | rs11928580 | chr3:41885722 | ULK4 | chr3:41288091-42003660:- | 0.5 | 6.03 | 1.17E-8 | Diastolic blood pressure |
| UCEC | cis | rs11976020 | 1 | rs11976020 | chr7:72247800 | TYW1B | chr7:72023729-72298813:- | 0.93 | 12.56 | 2.86E-25 | Educational attainment (years of education) |
| UCEC | cis | rs1577917 | 1 | rs12154056 | chr6:86634094 | SNHG5 | chr6:86386726-86388451:- | -0.42 | -4.96 | 1.9E-6 | Response to antipsychotic treatment |
| UCEC | cis | rs1577917 | 1 | rs12190598 | chr6:86686074 | SNHG5 | chr6:86386726-86388451:- | -0.43 | -4.98 | 1.67E-6 | Response to antipsychotic treatment |